Sickle Cell

Author Name: Alpine

Category Name: Microbiology

Description:

Sickle Cell Trait (SCT) person carries a single gene for Sickle Cell Disease (SCD) and can pass this gene along to their children. A rare but major concern in patients with sickle cell trait during major surgeries is the development of an intraoperative sickle cell crisis. Most people affected by the trait do not have any health problems caused by it but some do have problems if exposed to conditions causing stress or hypoxia.

Sickle Cell Trait (SCT) person carries a single gene for Sickle Cell Disease (SCD) and can pass this gene along to their children [1]. Usually they do not have any of the symptoms of SCD and live a normal life. SCT is more common among people whose ancestors come from Africa, the Mediterranean region, Middle East, and South Asia, but anyone can have SCT.

A rare but major concern is the development of an intraoperative sickle cell crisis especially when exposed to conditions of hypoxia.

There were no positive general examination findings. Local examination of the right lower limb showed swelling and tenderness over the right middle of thigh along with shortening, external rotation and abduction. The range of movements were restricted. Distal pulses were present.

Optimization of the clinical and hematology parameters was our utmost goal so as to undertake the planned surgery at the earliest. Exchange transfusion was planned so as to remove the sickle cells and give back normal red cells. Prior to the exchange transfusion the patient was pre-hydrated with intravenous fluids comprising of normal saline and ringer lactate. Venesection was done to remove 400 ml of patient’s blood. 1 unit of fresh PRBC (less than 5 day old) was given to him.

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Regards,

Alipine

Managing Editor

International journal of case report